|Application ||WB, E|
|Other Accession||P70060, P70662, O42252, O73715, NP_001106878.1, NP_003884.1|
|Predicted||Zebrafish, Chicken, Mouse, Xenopus|
|Calculated MW||46533 Da|
|Antigen Region||351-379 aa|
|Other Names||LIM domain-binding protein 1, LDB-1, Carboxyl-terminal LIM domain-binding protein 2, CLIM-2, LIM domain-binding factor CLIM2, hLdb1, Nuclear LIM interactor, LDB1, CLIM2|
|Target/Specificity||This LDB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 351-379 amino acids from the C-terminal region of human LDB1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LDB1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity).|
|Tissue Location||Expressed in a wide range of adult tissues including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
LDB1 binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. May play a role in the development of motor neurons. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity).
Howard, P.W., et al. Biochem. Biophys. Res. Commun. 396(3):674-678(2010)
Howard, P.W., et al. Biochem. J. 429(1):127-136(2010)
Bhati, M., et al. EMBO J. 27(14):2018-2029(2008)
Ryan, D.P., et al. Proteins 70(4):1461-1474(2008)
Tran, Y.H., et al. J. Biochem. 140(1):105-119(2006)
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