|Application ||WB, E|
|Other Accession||Q8VGC3, P54288, Q8CC27, Q9MZL5, NP_963864.1, NP_963890.2|
|Predicted||Bovine, Mouse, Rabbit, Rat|
|Calculated MW||73581 Da|
|Antigen Region||232-261 aa|
|Other Names||Voltage-dependent L-type calcium channel subunit beta-2, CAB2, Calcium channel voltage-dependent subunit beta 2, Lambert-Eaton myasthenic syndrome antigen B, MYSB, CACNB2, CACNLB2, MYSB|
|Target/Specificity||This CACNB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-261 amino acids from the Central region of human CACNB2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CACNB2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.|
|Cellular Location||Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Expressed in all tissues.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a subunit of a voltage-dependent calcium channel protein which is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome which is an autoimmune disorder. Mutations in this gene are associated with Brugada symdrome. Alternatively spliced variants have been identified for this gene.
Burashnikov, E., et al. Heart Rhythm (2010) In press :
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Takeuchi, F., et al. Circulation 121(21):2302-2309(2010)
Hong, K.W., et al. J. Hum. Genet. 55(6):336-341(2010)
Lee, M.T., et al. Mol. Psychiatry (2010) In press :
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