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ARHGEF1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ARHGEF1 Antibody (N-term) AP14869A
    ARHGEF1 Antibody (N-term) (Cat. #AP14869a) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ARHGEF1 antibody detected the ARHGEF1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92888
Other Accession NP_945328.1, NP_945353.1, NP_004697.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 102435 Da
Antigen Region 164-192 aa
Additional Information
Gene ID 9138
Other Names Rho guanine nucleotide exchange factor 1, 115 kDa guanine nucleotide exchange factor, p115-RhoGEF, p115RhoGEF, Sub15, ARHGEF1
Target/Specificity This ARHGEF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-192 amino acids from the N-terminal region of human ARHGEF1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsARHGEF1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation.
Cellular Location Cytoplasm. Membrane. Note=Translocated to the membrane by activated GNA13 or LPA stimulation
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Loirand, G., et al. Med Sci (Paris) 26 (6-7), 561-563 (2010) :
Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Slattum, G., et al. J. Cell Biol. 186(5):693-702(2009)

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$ 295.00
$ 99.00
Cat# AP14869A
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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