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ORC3L Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - ORC3L Antibody (N-term) AP14874a
    ORC3L Antibody (N-term) (Cat. #AP14874a) western blot analysis in SH-SY5Y cell line lysates (35ug/lane).This demonstrates the ORC3L antibody detected the ORC3L protein (arrow).
  • IHC-P - ORC3L Antibody (N-term) AP14874a
    ORC3L Antibody (N-term) (AP14874a)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung adenocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ORC3L Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UBD5
Other Accession NP_036513.2, NP_862820.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 82254 Da
Antigen Region 17-46 aa
Additional Information
Gene ID 23595
Other Names Origin recognition complex subunit 3, Origin recognition complex subunit Latheo, ORC3, LATHEO, ORC3L
Target/Specificity This ORC3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 amino acids from the N-terminal region of human ORC3L.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsORC3L Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ORC3
Synonyms LATHEO, ORC3L
Function Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Cellular Location Nucleus.
Research Areas
Citations (0)

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The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.


Enjuanes, A., et al. Cancer Res. 68(24):10178-10186(2008)
DeRosse, P., et al. Schizophr Bull 34(6):1047-1053(2008)
Siddiqui, K., et al. J. Biol. Chem. 282(44):32370-32383(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)

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Cat# AP14874a
(40 western blots)
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