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KEL Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - KEL Antibody (Center) AP14875c
    KEL Antibody (Center) (Cat. #AP14875c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the KEL antibody detected the KEL protein (arrow).
  • FC - KEL Antibody (Center) AP14875c
    KEL Antibody (Center) (Cat. #AP14875c) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P23276
Other Accession NP_000411.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 82824 Da
Antigen Region 214-243 aa
Additional Information
Gene ID 3792
Other Names Kell blood group glycoprotein, 3424-, CD238, KEL
Target/Specificity This KEL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-243 amino acids from the Central region of human KEL.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKEL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KEL
Function Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.
Cellular Location Cell membrane; Single-pass type II membrane protein. Note=Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton
Tissue Location Expressed at high levels in erythrocytes and testis (in Sertoli cells), and, at lower levels, in skeletal muscle, tonsils (in follicular dendritic cells), lymph node, spleen and appendix (at protein level). Also expressed in many adult and fetal nonerythroid tissues, including brain, spleen, lymph nodes and bone marrow.
Research Areas
Citations (0)

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This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases.


Di Cristofaro, J., et al. J Mol Diagn 12(4):453-460(2010)
Boturao-Neto, E., et al. Transfusion 50(3):735-737(2010)
Yang, Y., et al. Transfus Med 19(5):235-244(2009)
Kormoczi, G.F., et al. Transfusion 49(4):733-739(2009)
Lee, S., et al. Blood 102(8):3028-3034(2003)

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Cat# AP14875c
(40 western blots)
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