|Application ||WB, FC, E|
|Calculated MW||82824 Da|
|Antigen Region||214-243 aa|
|Other Names||Kell blood group glycoprotein, 3424-, CD238, KEL|
|Target/Specificity||This KEL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-243 amino acids from the Central region of human KEL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KEL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Note=Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton|
|Tissue Location||Expressed at high levels in erythrocytes and testis (in Sertoli cells), and, at lower levels, in skeletal muscle, tonsils (in follicular dendritic cells), lymph node, spleen and appendix (at protein level). Also expressed in many adult and fetal nonerythroid tissues, including brain, spleen, lymph nodes and bone marrow.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases.
Di Cristofaro, J., et al. J Mol Diagn 12(4):453-460(2010)
Boturao-Neto, E., et al. Transfusion 50(3):735-737(2010)
Yang, Y., et al. Transfus Med 19(5):235-244(2009)
Kormoczi, G.F., et al. Transfusion 49(4):733-739(2009)
Lee, S., et al. Blood 102(8):3028-3034(2003)
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