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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HYAL1 Antibody (C-term)   

HYAL1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - HYAL1 Antibody (C-term) AP14886b
    HYAL1 Antibody (C-term) (Cat. #AP14886b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the HYAL1 antibody detected the HYAL1 protein (arrow).
  • IHC-P - HYAL1 Antibody (C-term) AP14886b
    HYAL1 Antibody (C-term) (AP14886b)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HYAL1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q12794
Other Accession NP_695013.1, NP_695017.1, NP_009296.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 48368 Da
Antigen Region 280-309 aa
Additional Information
Gene ID 3373
Other Names Hyaluronidase-1, Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, LUCA1
Target/Specificity This HYAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-309 amino acids from the C-terminal region of human HYAL1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHYAL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HYAL1
Synonyms LUCA1
Function May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
Cellular Location Secreted. Lysosome
Tissue Location Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.
Research Areas
Citations (0)

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This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.


Lanktree, M.B., et al. Blood 116(12):2160-2163(2010)
Gasingirwa, M.C., et al. Biochem. J. 430(2):305-313(2010)
Tzuman, Y.C., et al. Neoplasia 12(1):51-60(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Wang, X.Y., et al. Chin. Med. J. 122(11):1300-1304(2009)

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$ 295.00
$ 99.00
Cat# AP14886b
(40 western blots)
Availability: In Stock
Bulk Size
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