|Application ||WB, IHC-P, E|
|Other Accession||NP_695013.1, NP_695017.1, NP_009296.1|
|Calculated MW||48368 Da|
|Antigen Region||280-309 aa|
|Other Names||Hyaluronidase-1, Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, LUCA1|
|Target/Specificity||This HYAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-309 amino acids from the C-terminal region of human HYAL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HYAL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.|
|Cellular Location||Secreted. Lysosome|
|Tissue Location||Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
Lanktree, M.B., et al. Blood 116(12):2160-2163(2010)
Gasingirwa, M.C., et al. Biochem. J. 430(2):305-313(2010)
Tzuman, Y.C., et al. Neoplasia 12(1):51-60(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Wang, X.Y., et al. Chin. Med. J. 122(11):1300-1304(2009)
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