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HYAL1 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP14886b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP14886b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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HYAL1 Antibody (C-term) - Product info | |
| Application | WB, IHC
|
| Primary Accession | Q12794 |
| Other Accession | NP_695013.1, NP_695017.1, NP_009296.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 48368 Da |
HYAL1 Antibody (C-term) - Additional info | |
| Gene ID 3373 | |
| Other Names HYAL1; LUCA1; Hyaluronidase-1; Hyaluronoglucosaminidase-1; Lung carcinoma protein 1 | |
| Target/Specificity This HYAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 279-309 amino acids from the C-terminal region of human HYAL1. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions HYAL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
HYAL1 Antibody (C-term) - Protein Information | |
| Name HYAL1 | |
| Synonyms LUCA1 | |
| Function May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth | |
| Cellular Location Secreted. Lysosome. | |
| Tissue Location Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues | |
HYAL1 Antibody (C-term) - Related products
AP14886b: HYAL1 Antibody (C-term)
RI12620: HYAL1 predesign siRNA
DC06924: Human HYAL1 cDNA Clone
HYAL1 Antibody (C-term) - Application data
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HYAL1 Antibody (C-term) (Cat. #AP14886b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the HYAL1 antibody detected the HYAL1 protein (arrow).
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HYAL1 Antibody (C-term) (AP14886b)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HYAL1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
HYAL1 Antibody (C-term) - Research Areas
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BACKGROUND
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Lanktree, M.B., et al. Blood 116(12):2160-2163(2010) Gasingirwa, M.C., et al. Biochem. J. 430(2):305-313(2010) Tzuman, Y.C., et al. Neoplasia 12(1):51-60(2010) Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) : Wang, X.Y., et al. Chin. Med. J. 122(11):1300-1304(2009)
