|Application ||WB, E|
|Other Accession||D3ZQG6, Q9ESN6, A4IF63, NP_056086.2, NP_001123539.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||81530 Da|
|Antigen Region||592-621 aa|
|Other Names||Tripartite motif-containing protein 2, 632-, E3 ubiquitin-protein ligase TRIM2, RING finger protein 86, TRIM2, KIAA0517, RNF86|
|Target/Specificity||This TRIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 592-621 amino acids from the C-terminal region of human TRIM2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRIM2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. Its function has not been identified. [provided by RefSeq].
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Ohkawa, N., et al. J. Neurochem. 78(1):75-87(2001)
Reymond, A., et al. EMBO J. 20(9):2140-2151(2001)
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