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NGDN Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NGDN Antibody (Center) AP14893C
    NGDN Antibody (Center) (Cat. #AP14893c) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the NGDN antibody detected the NGDN protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8NEJ9
Other Accession NP_056329.1, NP_001036100.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 35894 Da
Antigen Region 136-165 aa
Additional Information
Gene ID 25983
Other Names Neuroguidin, Centromere accumulated nuclear protein 1, CANu1, EIF4E-binding protein, NGDN, C14orf120
Target/Specificity This NGDN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-165 amino acids from the Central region of human NGDN.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNGDN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NGDN
Synonyms C14orf120
Function Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.
Cellular Location Nucleus. Nucleus, nucleolus. Chromosome, centromere. Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell projection, filopodium Note=Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites (By similarity). Translocated from nucleolus to nuclear foci in response to UV damage.
Citations (0)

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Background

Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).

References

Sihn, C.R., et al. Genes Cells 13(8):787-796(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Jung, M.Y., et al. Mol. Cell. Biol. 26(11):4277-4287(2006)
Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)

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Cat# AP14893C
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(40 western blots)
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