|Application ||WB, E|
|Other Accession||NP_056329.1, NP_001036100.1|
|Calculated MW||35894 Da|
|Antigen Region||136-165 aa|
|Other Names||Neuroguidin, Centromere accumulated nuclear protein 1, CANu1, EIF4E-binding protein, NGDN, C14orf120|
|Target/Specificity||This NGDN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-165 amino acids from the Central region of human NGDN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NGDN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.|
|Cellular Location||Nucleus. Nucleus, nucleolus. Chromosome, centromere. Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell projection, filopodium Note=Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites (By similarity). Translocated from nucleolus to nuclear foci in response to UV damage.|
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Provided below are standard protocols that you may find useful for product applications.
Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).
Sihn, C.R., et al. Genes Cells 13(8):787-796(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Jung, M.Y., et al. Mol. Cell. Biol. 26(11):4277-4287(2006)
Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)
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