|Application ||WB, E|
|Calculated MW||34095 Da|
|Antigen Region||123-151 aa|
|Other Names||Epidermal retinol dehydrogenase 2, EPHD-2, RDH-E2, Retinal short-chain dehydrogenase reductase 2, retSDR2, Short-chain dehydrogenase/reductase family 16C member 5, SDR16C5, RDHE2|
|Target/Specificity||This SDR16C5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-151 amino acids from the Central region of human SDR16C5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SDR16C5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Detected in adult lung. Detected at low levels in adult brain, heart, testis, placenta, cervix, pancreas, uterus, stomach, rectum, small intestine, colon, esophagus, thymus, skin, and skin keratinocyte. Expression is higher in psoriasis lesions relative to unaffected skin from psoriasis patients. Detected in fetal kidney, skin and lung.|
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Provided below are standard protocols that you may find useful for product applications.
RDHE2 belongs to a family of short-chain alcohol dehydrogenases/reductases that catalyze the first and rate-limiting step that generates retinaldehyde from retinol (Matsuzaka et al., 2002 [PubMed 12372410]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
Takahashi, Y., et al. Biochem. J. 419(1):113-122(2009)
Soranzo, N., et al. PLoS Genet. 5 (4), E1000445 (2009) :
Lee, S.A., et al. Chem. Biol. Interact. 178 (1-3), 182-187 (2009) :
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