- CITATIONS: 1
|Application ||WB, FC, E|
|Calculated MW||57490 Da|
|Antigen Region||31-60 aa|
|Other Names||Solute carrier family 2, facilitated glucose transporter member 2, Glucose transporter type 2, liver, GLUT-2, SLC2A2, GLUT2|
|Target/Specificity||This GLUT2 (SLC2A2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-60 amino acids from the N-terminal region of human GLUT2 (SLC2A2).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GLUT2 (SLC2A2) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Liver, insulin-producing beta cell, small intestine and kidney|
Provided below are standard protocols that you may find useful for product applications.
Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor.
Freitas,H.S., Nephron Physiol 105 (3), P42-P51 (2007) Laukkanen,O., Diabetes 54 (7), 2256-2260 (2005) Roncero,I., J. Neurochem. 88 (5), 1203-1210 (2004)
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