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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DVL2 Antibody (C-term)   

DVL2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - DVL2 Antibody (C-term) AP14900b
    DVL2 Antibody (C-term) (Cat. #AP14900b) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the DVL2 antibody detected the DVL2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O14641
Other Accession Q60838, NP_004413.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 78948 Da
Antigen Region 588-617 aa
Additional Information
Gene ID 1856
Other Names Segment polarity protein dishevelled homolog DVL-2, Dishevelled-2, DSH homolog 2, DVL2
Target/Specificity This DVL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-617 amino acids from the C-terminal region of human DVL2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDVL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DVL2
Function Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).
Cellular Location Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cytosol. Cytoplasmic vesicle. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity)
Research Areas
Citations (0)

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This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.


Inkster, B., et al. Neuroimage 53(3):908-917(2010)
Kikuchi, K., et al. EMBO J. 29(20):3470-3483(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Gao, C., et al. Nat. Cell Biol. 12(8):781-790(2010)
Gnad, T., et al. Mol. Cancer 9, 31 (2010) :

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$ 295.00
$ 99.00
Cat# AP14900b
(40 western blots)
Availability: In Stock
Bulk Size
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