|Application ||WB, IF, E|
|Other Accession||NP_005896.1, NP_001120689.1|
|Calculated MW||52493 Da|
|Antigen Region||200-228 aa|
|Other Names||Mothers against decapentaplegic homolog 9, MAD homolog 9, Mothers against DPP homolog 9, Madh6, SMAD family member 9, SMAD 9, Smad9, SMAD9, MADH6, MADH9|
|Target/Specificity||This SMAD9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-228 amino acids from the Central region of human SMAD9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SMAD9 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).|
|Cellular Location||Cytoplasm. Nucleus. Note=In the cytoplasm in the absence of ligand Migration to the nucleus when complexed with SMAD4 (By similarity).|
|Tissue Location||Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Liu, Y., et al. FASEB J. 23(7):2299-2306(2009)
Su, D., et al. J. Biol. Chem. 284(18):12153-12164(2009)
Shintani, M., et al. J. Med. Genet. 46(5):331-337(2009)
Hoover, L.L., et al. Sci Signal 1 (46), PE48 (2008) :
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