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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CCT4 Antibody (N-term)   

CCT4 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CCT4 Antibody (N-term) AP14904a
    CCT4 Antibody (N-term) (Cat. #AP14904a) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CCT4 antibody detected the CCT4 protein (arrow).
  • IHC-P - CCT4 Antibody (N-term) AP14904a
    CCT4 Antibody (N-term) (AP14904a)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CCT4 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P50991
Other Accession Q7TPB1, NP_006421.2
Reactivity Human
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 57924 Da
Antigen Region 4-32 aa
Additional Information
Gene ID 10575
Other Names T-complex protein 1 subunit delta, TCP-1-delta, CCT-delta, Stimulator of TAR RNA-binding, CCT4, CCTD, SRB
Target/Specificity This CCT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the N-terminal region of human CCT4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCT4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCT4
Synonyms CCTD, SRB
Function Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
Cellular Location Cytoplasm. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Research Areas
Citations (0)

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The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).


Mukherjee, K., et al. BMC Evol. Biol. 10, 64 (2010) :
Zebol, J.R., et al. Int. J. Biochem. Cell Biol. 41(4):822-827(2009)
Chi, A., et al. J. Proteome Res. 5(11):3135-3144(2006)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
Imai, Y., et al. J. Biol. Chem. 278(51):51901-51910(2003)

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$ 295.00
$ 99.00
Cat# AP14904a
(40 western blots)
Availability: In Stock
Bulk Size
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