|Application ||WB, FC, IHC-P, E|
|Other Accession||NP_001321.1, NP_001136016.1|
|Calculated MW||21227 Da|
|Antigen Region||166-194 aa|
|Other Names||Cardiotrophin-1, CT-1, CTF1|
|Target/Specificity||This CTF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-194 amino acids from the C-terminal region of human CTF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CTF1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.|
|Tissue Location||Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene.
Robador, P.A., et al. J. Hypertens. (2010) In press :
Bailey, S.D., et al. Diabetes Care (2010) In press :
Limongelli, G., et al. Cytokine 50(3):245-247(2010)
Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)
Fritzenwanger, M., et al. Mediators Inflamm. 2009, 489802 (2009) :
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