|Application ||WB, E|
|Other Accession||Q9QX72, NP_076982.3|
|Calculated MW||95462 Da|
|Antigen Region||501-530 aa|
|Other Names||Selenocysteine insertion sequence-binding protein 2, SECIS-binding protein 2, SECISBP2, SBP2|
|Target/Specificity||This SECISBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 501-530 amino acids from the Central region of human SECISBP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SECISBP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.|
|Cellular Location||Isoform 1: Nucleus.|
|Tissue Location||Expressed at high levels in testis.|
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Provided below are standard protocols that you may find useful for product applications.
The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.
Meplan, C., et al. Carcinogenesis 31(6):1074-1079(2010)
Papp, L.V., et al. Antioxid. Redox Signal. 12(7):797-808(2010)
Di Cosmo, C., et al. J. Clin. Endocrinol. Metab. 94(10):4003-4009(2009)
Olieric, V., et al. Biochimie 91(8):1003-1009(2009)
Schomburg, L., et al. Thyroid 19(3):277-281(2009)
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