|Application ||WB, IHC-P, E|
|Other Accession||NP_001158077.1, NP_659003.1|
|Calculated MW||19472 Da|
|Antigen Region||71-100 aa|
|Other Names||FXYD domain-containing ion transport regulator 5, Dysadherin, FXYD5, DYSAD, IWU1|
|Target/Specificity||This FXYD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the Central region of human FXYD5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FXYD5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., email@example.com.].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Ono, K., et al. Anticancer Res. 30(9):3273-3278(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Liang, J.F., et al. Pathol. Res. Pract. 205(7):445-450(2009)
Batistatou, A., et al. Endocr. Pathol. 19(3):197-202(2008)
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