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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FXYD5 Antibody (Center)   

FXYD5 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FXYD5 Antibody (Center) AP14909c
    FXYD5 Antibody (Center) (Cat. #AP14909c) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the FXYD5 antibody detected the FXYD5 protein (arrow).
  • IHC-P - FXYD5 Antibody (Center) AP14909c
    FXYD5 Antibody (Center) (AP14909c)immunohistochemistry analysis in formalin fixed and paraffin embedded human rectum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FXYD5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96DB9
Other Accession NP_001158077.1, NP_659003.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 19472 Da
Antigen Region 71-100 aa
Additional Information
Gene ID 53827
Other Names FXYD domain-containing ion transport regulator 5, Dysadherin, FXYD5, DYSAD, IWU1
Target/Specificity This FXYD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the Central region of human FXYD5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFXYD5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FXYD5
Synonyms DYSAD, IWU1
Function Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D.,].


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Ono, K., et al. Anticancer Res. 30(9):3273-3278(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Liang, J.F., et al. Pathol. Res. Pract. 205(7):445-450(2009)
Batistatou, A., et al. Endocr. Pathol. 19(3):197-202(2008)

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Cat# AP14909c
(40 western blots)
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