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ADAM17 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP1492b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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ADAM17 Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | P78536 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 93021 Da |
ADAM17 Antibody (C-term) - Additional info | |
| Gene ID 6868 | |
| Other Names ADAM17; CSVP; TACE; Disintegrin and metalloproteinase domain-containing protein 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD_antigen=CD156b; Flags: Precursor | |
| Target/Specificity This ADAM17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 795~824 amino acids from the C-terminal region of human ADAM17. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Then the antibody is purified by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ADAM17 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ADAM17 Antibody (C-term) - Protein Information | |
| Name ADAM17 | |
| Synonyms CSVP, TACE | |
| Function Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity) | |
| Cellular Location Membrane; Single-pass type I membrane protein | |
| Tissue Location Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney | |
ADAM17 Antibody (C-term) - Related products
AP1492a: ADAM17 Antibody (N-term)
AP1492b: ADAM17 Antibody (C-term)
RI10112: ADAM17 predesign siRNA
DC08282: Human ADAM17 cDNA Clone
LY11937a: ADAM17 Over-expression Lysate
BP1492a: ADAM17 Antibody (N-term) Blocking Peptide
ADAM17 Antibody (C-term) - Application data
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Western blot analysis of ADAM17 Antibody (N-term) in Jurkat cell line lysates (35ug/lane). ADAM17(arrow) was detected using the purified Pab (1:60 dilution).
ADAM17 Antibody (C-term) - Research Areas
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BACKGROUND
ADAM17 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM17 functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.
REFERENCES
Tellier,E., J. Cell. Physiol. 214 (3), 687-693 (2008) Takamune,Y., Biochem. Biophys. Res. Commun. 365 (2), 393-398 (2008)
