|Application ||WB, E|
|Other Accession||P20781, P48168, Q9GJS9, NP_001159532.1, NP_000815.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||56122 Da|
|Antigen Region||103-132 aa|
|Other Names||Glycine receptor subunit beta, Glycine receptor 58 kDa subunit, GLRB|
|Target/Specificity||This GLRB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-132 amino acids from the N-terminal region of human GLRB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GLRB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants.
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :
Ziegler, E., et al. Naunyn Schmiedebergs Arch. Pharmacol. 380(4):277-291(2009)
Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
Ahrens, J., et al. Pharmacology 83(4):217-222(2009)
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