|Application ||WB, IHC-P, E|
|Other Accession||NP_001123551.1, NP_066014.1|
|Calculated MW||113671 Da|
|Antigen Region||260-288 aa|
|Other Names||Putative helicase MOV-10, Moloney leukemia virus 10 protein, MOV10, KIAA1631|
|Target/Specificity||This MOV10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-288 amino acids from the N-terminal region of human MOV10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MOV10 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA- mediated cleavage of complementary mRNAs by RISC. Also required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.|
|Cellular Location||Cytoplasm, P-body|
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Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.
El Messaoudi-Aubert, S., et al. Nat. Struct. Mol. Biol. 17(7):862-868(2010) Furtak, V., et al. PLoS ONE 5 (2), E9081 (2010) : Nakano, M., et al. Biochem. Biophys. Res. Commun. 388(2):328-332(2009) Haussecker, D., et al. Nat. Struct. Mol. Biol. 15(7):714-721(2008) Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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