|Application ||WB, E|
|Other Accession||Q9GKU5, NP_079103.2|
|Calculated MW||39183 Da|
|Antigen Region||197-226 aa|
|Other Names||Histone deacetylase 11, HD11, HDAC11|
|Target/Specificity||This HDAC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197-226 amino acids from the Central region of human HDAC11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HDAC11 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|
|Cellular Location||Nucleus. Note=Predominantly nuclear.|
|Tissue Location||Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.
Janssen, C., et al. J. Neuropathol. Exp. Neurol. 69(6):573-581(2010)
Glozak, M.A., et al. J. Biol. Chem. 284(17):11446-11453(2009)
Georgopoulos, K. Nat. Immunol. 10(1):13-14(2009)
Villagra, A., et al. Nat. Immunol. 10(1):92-100(2009)
Fournel, M., et al. Mol. Cancer Ther. 7(4):759-768(2008)
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