|Application ||WB, E|
|Calculated MW||57831 Da|
|Antigen Region||39-68 aa|
|Other Names||Serine/threonine-protein kinase 33, STK33|
|Target/Specificity||This STK33 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from the N-terminal region of human STK33.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||STK33 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines.|
|Cellular Location||Cytoplasm, perinuclear region.|
|Tissue Location||Highly expressed in testis, fetal lung and heart, followed by pituitary gland, kidney, interventricular septum, pancreas, heart, trachea, thyroid gland and uterus. Weak hybridization signals were observed in the following tissues: amygdala, aorta, esophagus, colon ascending, colon transverse, skeletal muscle, spleen, peripheral blood leukocyte, lymph node, bone marrow, placenta, prostate, liver, salivary gland, mammary gland, some tumor cell lines, fetal brain, fetal liver, fetal spleen and fetal thymus. No signal at all was detectable in RNA from tissues of the nervous system.|
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Provided below are standard protocols that you may find useful for product applications.
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain.
Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162(2010)
Willer, C.J., et al. Nat. Genet. 41(1):25-34(2009)
Mujica, A.O., et al. FEBS J. 272(19):4884-4898(2005)
Mujica, A.O., et al. Gene 280 (1-2), 175-181 (2001) :
Amid, C., et al. Cytogenet. Cell Genet. 93 (3-4), 284-290 (2001) :
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