|Application ||WB, IHC-P, IF, FC, E|
|Other Accession||Q9QYV8, P54099, NP_001119603.1, NP_002684.1|
|Calculated MW||139562 Da|
|Antigen Region||1120-1148 aa|
|Other Names||DNA polymerase subunit gamma-1, Mitochondrial DNA polymerase catalytic subunit, PolG-alpha, POLG, MDP1, POLG1, POLGA|
|Target/Specificity||This POLG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1120-1148 amino acids from the C-terminal region of human POLG.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||POLG Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MDP1, POLG1, POLGA|
|Function||Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.|
|Cellular Location||Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid|
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Provided below are standard protocols that you may find useful for product applications.
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.
Tong, Z.B., et al. Fertil. Steril. 94(7):2932-2934(2010)
Stewart, J.D., et al. Hepatology 52(5):1791-1796(2010)
Batabyal, D., et al. J. Biol. Chem. 285(44):34191-34201(2010)
Wang, W., et al. Nucleic Acids Res. (2010) In press :
Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)
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