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Mouse Clk3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O35492 |
| Other Accession | NP_031739.3 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 73798 Da |
| Antigen Region | 20-48 aa |
| Gene ID | 102414 |
|---|---|
| Other Names | Dual specificity protein kinase CLK3, CDC-like kinase 3, Clk3 |
| Target/Specificity | This Mouse Clk3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-48 amino acids from the N-terminal region of mouse Clk3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Clk3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Clk3 |
|---|---|
| Function | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine- rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre- mRNA in endothelial cells. |
| Cellular Location | Nucleus. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome |
| Tissue Location | Present at high levels in testis and ovary. In testis, expression is restricted to elongated, maturing spermatozoa Also present in spleen, brain, lung and liver (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphorylates serine-and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines.
References
Sansom, S.N., et al. PLoS Genet. 5 (6), E1000511 (2009) :
Carrier, A., et al. Immunogenetics 50 (5-6), 255-270 (1999) :
Nayler, O., et al. Biochem. J. 326 (PT 3), 693-700 (1997) :
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