|Application ||WB, E|
|Other Accession||Q9CUN6, NP_851994.1, NP_065162.1|
|Calculated MW||86114 Da|
|Antigen Region||352-381 aa|
|Other Names||E3 ubiquitin-protein ligase SMURF1, hSMURF1, 632-, SMAD ubiquitination regulatory factor 1, SMAD-specific E3 ubiquitin-protein ligase 1, SMURF1, KIAA1625|
|Target/Specificity||This SMURF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 352-381 amino acids from the Central region of human SMURF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SMURF1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (PubMed:23999003).|
|Cellular Location||Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Expressed in melanocytes (PubMed:23999003).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. A similar protein in Xenopus is involved in embryonic pattern formation. Alternative splicing results in multiple transcript variants encoding different isoforms. An additional transcript variant has been identified, but its full length sequence has not been determined.
Li, S., et al. Mol. Cell. Biochem. 338 (1-2), 11-17 (2010) :
Franke, A., et al. Nat. Genet. 42(4):292-294(2010)
Alarcon, C., et al. Cell 139(4):757-769(2009)
Crose, L.E., et al. J. Biol. Chem. 284(20):13301-13305(2009)
Narimatsu, M., et al. Cell 137(2):295-307(2009)
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