Mouse Acvr2a Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P27038 |
Other Accession | P38444, NP_031422.3 |
Reactivity | Mouse |
Predicted | Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 57890 Da |
Antigen Region | 22-49 aa |
Gene ID | 11480 |
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Other Names | Activin receptor type-2A, Activin receptor type IIA, ACTR-IIA, Acvr2a, Acvr2 |
Target/Specificity | This Mouse Acvr2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-49 amino acids from the N-terminal region of mouse Acvr2a. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Acvr2a Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Acvr2a {ECO:0000312|MGI:MGI:102806} |
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Synonyms | Acvr2 |
Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (PubMed:23527555). |
Cellular Location | Cell membrane; Single-pass type I membrane protein |
Tissue Location | Brain, testis, intestine, liver and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
References
Perron, J.C., et al. PLoS ONE 4 (12), E8198 (2009) :
Morita, S., et al. PLoS ONE 4 (1), E4212 (2009) :
Kamiya, N., et al. Development 135(22):3801-3811(2008)
Xia, Y., et al. J. Biol. Chem. 282(25):18129-18140(2007)
Lee, Y.J., et al. Genesis 44(10):487-494(2006)
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