|Application ||WB, E|
|Other Accession||P38444, NP_031422.3|
|Calculated MW||57890 Da|
|Antigen Region||22-49 aa|
|Other Names||Activin receptor type-2A, Activin receptor type IIA, ACTR-IIA, Acvr2a, Acvr2|
|Target/Specificity||This Mouse Acvr2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-49 amino acids from the N-terminal region of mouse Acvr2a.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Acvr2a Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (PubMed:23527555).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Brain, testis, intestine, liver and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
Perron, J.C., et al. PLoS ONE 4 (12), E8198 (2009) :
Morita, S., et al. PLoS ONE 4 (1), E4212 (2009) :
Kamiya, N., et al. Development 135(22):3801-3811(2008)
Xia, Y., et al. J. Biol. Chem. 282(25):18129-18140(2007)
Lee, Y.J., et al. Genesis 44(10):487-494(2006)
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