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KLF2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 3
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y5W3 |
| Other Accession | NP_057354.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37420 Da |
| Antigen Region | 13-42 aa |
| Gene ID | 10365 |
|---|---|
| Other Names | Krueppel-like factor 2, Lung krueppel-like factor, KLF2, LKLF |
| Target/Specificity | This KLF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the N-terminal region of human KLF2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KLF2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KLF2 |
|---|---|
| Synonyms | LKLF |
| Function | Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758). |
| Cellular Location | Nucleus. |
Provided below are standard protocols that you may find useful for product applications.
Background
KLF2 binds to the CACCC box in the beta-globin gene promoter and activates transcription (By similarity).
References
Lin, Z., et al. Arterioscler. Thromb. Vasc. Biol. 30(10):1952-1959(2010)
Zahlten, J., et al. J. Immunol. 185(1):597-604(2010)
Wang, W., et al. Blood 115(14):2971-2979(2010)
Boon, R.A., et al. Blood 115(12):2533-2542(2010)
Villarreal, G. Jr., et al. Biochem. Biophys. Res. Commun. 391(1):984-989(2010)
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