|Application ||WB, E|
|Calculated MW||24075 Da|
|Antigen Region||17-45 aa|
|Other Names||Protein CREG1, Cellular repressor of E1A-stimulated genes 1, CREG1, CREG|
|Target/Specificity||This CREG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of human CREG1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CREG1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.|
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Provided below are standard protocols that you may find useful for product applications.
The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation.
Han, Y., et al. J. Mol. Cell. Cardiol. 48(6):1225-1235(2010)
Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)
Han, Y., et al. Exp. Cell Res. 315(19):3301-3311(2009)
Bian, Z., et al. J. Cell. Mol. Med. 13(7):1302-1313(2009)
Cheung, C.L., et al. Hum. Mol. Genet. 18(4):679-687(2009)
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