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M TLR4 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

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United States
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Ordering Information
Catalog # SizeAvailability Price  
AP1504a 400 µl
(40 western blots)
In Stock
$ 265.00email & fax$ 251.75online
Add to cart
AP1504a-ev 80 µl
(8 western blots)
In Stock
$ 95.00email & fax$ 90.25online
Add to cart
  • Specification
  • Citations : 1
  • Reviews
  • Protocols
  • Background

M TLR4 Antibody (N-term) - Product info

Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary AccessionQ9QUK6
ReactivityMouse
Isotype Rabbit Ig
Calculated MW 95519 Da

M TLR4 Antibody (N-term) - Additional info

Gene ID 21898
Other Names
Tlr4; Lps; Toll-like receptor 4; CD_antigen=CD284; Flags: Precursor
Target/Specificity
This Mouse TLR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-55 amino acids from the N-terminal region of mouse TLR4.
Dilution
WB~~1:1000
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
M TLR4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.

M TLR4 Antibody (N-term) - Protein Information

Name Tlr4
Synonyms Lps
Function
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
Cellular Location
Membrane; Single-pass type I membrane protein (By similarity)
Tissue Location
Highly expressed in heart, spleen, lung and muscle. Lower levels are found in liver and kidney

M TLR4 Antibody (N-term) - Related products

AP9685c: TLR4 Antibody (Center)

BP1504a: Mouse TLR4 Antibody (N-term) Blocking Peptide

AT4256a: TLR4 Antibody (monoclonal) (M03)

M TLR4 Antibody (N-term) - Research Areas

  • Arteriogenesis requires toll-like receptor 2 and 4 expression in bone-marrow derived cells. Author : de Groot D, Hoefer IE, Grundmann S, Schoneveld A, Haverslag RT, van Keulen JK, Bot PT, Timmers L, Piek JJ, Pasterkamp G, de Kleijn DP.
    J Mol Cell Cardiol. 2011 Jan;50(1):25-32. doi: 10.1016/j.yjmcc.2010.08.006. Epub 2010 Aug 12.
    PubMed® Id : 20708624

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Provided below are standard protocols that you may find useful for product applications.

BACKGROUND

TLR4, a type I membrane protein that belongs to the Toll-like receptor family, cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). It acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response TLR4 Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR. TLR4 binds to LY96 via the extracellular domain, and to MyD88 and TIRAP via their respective TIR domains. The protein contains 19 leucine-rich (LRR) repeats, and It is highly expressed in heart, spleen, lung and muscle. Lower levels are found in liver and kidney. Interstrain analyses reveal that TLR4 is a polymorphic protein and that the extracellular domain is far more variable than the cytoplasmic domain, which is variable at the C-terminal.