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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   M TLR4 Antibody (N-term)   

M TLR4 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

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Ordering Information
Catalog # SizeAvailability Price  
AP1504a 400 µl
(40 western blots)
In Stock $ 265.00 Add to cart
AP1504a-ev 80 µl
(8 western blots)
In Stock $ 95.00 Add to cart
  • Specification
  • Citations : 3
  • Reviews
  • Protocols
  • Background

M TLR4 Antibody (N-term) - Product Information

  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • ICC=Immunocytochemistry
  • CHIP=Chromatin Immunoprecipitation
  • IHCF=Immunohistochemistry (Frozen Sections)
  • FA=Fluorescence Assay
  • IHCP=Immunohistochemistry (Paraffin-embedded Sections)
  • IC=Immunochemistry
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary AccessionQ9QUK6
Isotype Rabbit Ig
Calculated MW 95519 Da
Antigen Region 25-55 aa

M TLR4 Antibody (N-term) - Additional Information

Gene ID 21898
Other Names
Toll-like receptor 4, CD284, Tlr4, Lps
This Mouse TLR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-55 amino acids from the N-terminal region of mouse TLR4.
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
M TLR4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.

M TLR4 Antibody (N-term) - Protein Information

Name Tlr4
Synonyms Lps
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS- independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low- density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42- binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.
Cellular Location
Cell membrane {ECO:0000250|UniProtKB:O00206}; Single-pass type I membrane protein. Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis {ECO:0000250|UniProtKB:O00206}
Tissue Location
Highly expressed in heart, spleen, lung and muscle. Lower levels are found in liver and kidney

M TLR4 Antibody (N-term) - Related Products

AP9685c: TLR4 Antibody (Center)

BP1504a: Mouse TLR4 Antibody (N-term) Blocking Peptide

AT4256a: TLR4 Antibody (monoclonal) (M03)

M TLR4 Antibody (N-term) - Research Areas

  • Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma. Author : Chi W1, Li F1, Chen H1, Wang Y1, Zhu Y1, Yang X1, Zhu J2, Wu F2, Ouyang H2, Ge J1, Weinreb RN2, Zhang K3, Zhuo Y4 Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11181-6. doi: 10.1073/pnas.1402819111. Epub 2014 Jul 14.
    PubMed® Id : 25024200
  • The tumor suppressor p15Ink4b regulates the differentiation and maturation of conventional dendritic cells. Author : Fares J1, Koller R, Humeniuk R, Wolff L, Bies J.
    Blood. 2012 May 24;119(21):5005-15. doi: 10.1182/blood-2011-10-387613. Epub 2012 Mar 28.
    PubMed® Id : 22461492
  • Arteriogenesis requires toll-like receptor 2 and 4 expression in bone-marrow derived cells. Author : de Groot D, Hoefer IE, Grundmann S, Schoneveld A, Haverslag RT, van Keulen JK, Bot PT, Timmers L, Piek JJ, Pasterkamp G, de Kleijn DP.
    J Mol Cell Cardiol. 2011 Jan;50(1):25-32. doi: 10.1016/j.yjmcc.2010.08.006. Epub 2010 Aug 12.
    PubMed® Id : 20708624

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Provided below are standard protocols that you may find useful for product applications.


TLR4, a type I membrane protein that belongs to the Toll-like receptor family, cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). It acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response TLR4 Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR. TLR4 binds to LY96 via the extracellular domain, and to MyD88 and TIRAP via their respective TIR domains. The protein contains 19 leucine-rich (LRR) repeats, and It is highly expressed in heart, spleen, lung and muscle. Lower levels are found in liver and kidney. Interstrain analyses reveal that TLR4 is a polymorphic protein and that the extracellular domain is far more variable than the cytoplasmic domain, which is variable at the C-terminal.