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M TLR4 Antibody (N-term)Purified Rabbit Polyclonal Antibody (Pab)
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|AP1504a||400 µl (40 western blots)||In Stock||$ 265.00||DISCONTINUED INQUIRE CLICK INQUIRE Add to cart|
|AP1504a-ev||80 µl (8 western blots)||In Stock||$ 95.00||DISCONTINED INQUIRE CLICK INQUIRE Add to cart|
- Citations : 1
M TLR4 Antibody (N-term) - Product info
|Calculated MW||95519 Da|
M TLR4 Antibody (N-term) - Additional info
|Gene ID 21898|
Tlr4; Lps; Toll-like receptor 4; CD_antigen=CD284; Flags: Precursor
This Mouse TLR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-55 amino acids from the N-terminal region of mouse TLR4.
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
M TLR4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
M TLR4 Antibody (N-term) - Protein Information
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
Membrane; Single-pass type I membrane protein (By similarity)
Highly expressed in heart, spleen, lung and muscle. Lower levels are found in liver and kidney
M TLR4 Antibody (N-term) - Related products
M TLR4 Antibody (N-term) - Application data
Western blot analysis of anti-mTLR4 Pab (Cat. #AP1504a) in mouse spleen cell lysate. mTLR4 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
M TLR4 Antibody (N-term) - Research Areas
Arteriogenesis requires toll-like receptor 2 and 4 expression in bone-marrow derived cells.
Author : de Groot D, Hoefer IE, Grundmann S, Schoneveld A, Haverslag RT, van Keulen JK, Bot PT, Timmers L, Piek JJ, Pasterkamp G, de Kleijn DP.
J Mol Cell Cardiol. 2011 Jan;50(1):25-32. doi: 10.1016/j.yjmcc.2010.08.006. Epub 2010 Aug 12.
PubMed® Id : 20708624
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Provided below are standard protocols that you may find useful for product applications.
TLR4, a type I membrane protein that belongs to the Toll-like receptor family, cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). It acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response TLR4 Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR. TLR4 binds to LY96 via the extracellular domain, and to MyD88 and TIRAP via their respective TIR domains. The protein contains 19 leucine-rich (LRR) repeats, and It is highly expressed in heart, spleen, lung and muscle. Lower levels are found in liver and kidney. Interstrain analyses reveal that TLR4 is a polymorphic protein and that the extracellular domain is far more variable than the cytoplasmic domain, which is variable at the C-terminal.