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M TLR4 Antibody (N-term)Purified Rabbit Polyclonal Antibody (Pab)

Country
United States
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Ordering Information
Catalog # Size Availability Price  
AP1504a 400 µl (40 western blots) In Stock $ 265.00 Add to cart
AP1504a-ev 80 µl (8 western blots) In Stock $ 95.00 Add to cart
  • Specification
  • Citations : 1
  • Reviews
  • Protocols
  • Background

M TLR4 Antibody (N-term) - Product info

ApplicationWB
  • Applications Legend:
  • WB=Western Blotting
  • IP=Immunoprecipitation
  • IHC-P=Immunohistochemistry (Paraffin)
  • IF-IC=Immunofluorescence (Immunocytochemistry)
  • FC=Flow Cytometry
  • DB=Dot Blot
Primary AccessionQ9QUK6
ReactivityMouse
IsotypeRabbit Ig
Calculated MW95519 Da

M TLR4 Antibody (N-term) - Additional info

Gene ID 21898
Other Names
Tlr4; Lps; Toll-like receptor 4; CD_antigen=CD284; Flags: Precursor
Target/Specificity
This Mouse TLR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-55 amino acids from the N-terminal region of mouse TLR4.
Dilution
WB~~1:1000
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
M TLR4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.

M TLR4 Antibody (N-term) - Protein Information

Name Tlr4
Synonyms Lps
Function
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
Cellular Location
Membrane; Single-pass type I membrane protein (By similarity)
Tissue Location
Highly expressed in heart, spleen, lung and muscle. Lower levels are found in liver and kidney

M TLR4 Antibody (N-term) - Related products

AP9685c: TLR4 Antibody (Center)

BP1504a: Mouse TLR4 Antibody (N-term) Blocking Peptide

AT4255a: TLR4 Antibody (monoclonal) (M02)

AT4256a: TLR4 Antibody (monoclonal) (M03)

M TLR4 Antibody (N-term) - Application data

  • Western blot analysis of anti-mTLR4 Pab (Cat. #AP1504a) in mouse spleen cell lysate. mTLR4 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

M TLR4 Antibody (N-term) - Research Areas

AntibodiesGene OntologyBiological ProcessSignal TransductionCellular ProcessPositive Regulation Of Biological ProcessPositive Regulation Of Cellular ProcessResponse To Organic SubstancePositive Regulation Of Cellular Metabolic ProcessPositive Regulation Of Metabolic ProcessPositive Regulation Of Macromolecule Metabolic ProcessRegulation Of PhosphorylationResponse To Chemical StimulusRegulation Of Phosphate Metabolic ProcessRegulation Of Phosphorus Metabolic ProcessPositive Regulation Of Biosynthetic ProcessPositive Regulation Of Cellular Biosynthetic ProcessIntracellular Signaling CascadeProtein Kinase CascadePositive Regulation Of Macromolecule Biosynthetic ProcessRegulation Of Cell ProliferationRegulation Of Kinase ActivityRegulation Of Protein Kinase ActivityRegulation Of Transferase ActivityRegulation Of Molecular FunctionPositive Regulation Of Molecular FunctionPositive Regulation Of Cell ProliferationRegulation Of Catalytic ActivityRegulation Of Cell CommunicationRegulation Of Response To StimulusPositive Regulation Of Catalytic ActivityPositive Regulation Of Kinase ActivityPositive Regulation Of Protein Kinase ActivityRegulation Of Multicellular Organismal ProcessRegulation Of Signal TransductionRegulation Of Response To StressPositive Regulation Of Transferase ActivityRegulation Of Protein Kinase CascadeRegulation Of Immune System ProcessRegulation Of Stress-activated Protein Kinase Signaling PathwayPositive Regulation Of Signal TransductionRegulation Of Cellular Response To StressResponse To StressPositive Regulation Of Cell CommunicationRegulation Of MAPKKK CascadeRegulation Of JNK CascadeResponse To External StimulusRegulation Of Metabolic ProcessRegulation Of BindingRegulation Of Cytokine ProductionRegulation Of Cellular Metabolic ProcessPositive Regulation Of Protein Kinase CascadeRegulation Of Transcription Factor ActivityPositive Regulation Of Response To StimulusResponse To WoundingRegulation Of DNA BindingRegulation Of Cytokine Biosynthetic ProcessMulti-organism ProcessBiological RegulationRegulation Of Macromolecule Metabolic ProcessResponse To Molecule Of Bacterial OriginPositive Regulation Of Stress-activated Protein Kinase Signaling PathwayRegulation Of Defense ResponseResponse To LipopolysaccharideRegulation Of Leukocyte ProliferationRegulation Of Mononuclear Cell ProliferationRegulation Of Lymphocyte ProliferationPositive Regulation Of NF-kappaB Transcription Factor ActivityPositive Regulation Of Transcription Factor ActivityPositive Regulation Of BindingRegulation Of Primary Metabolic ProcessPositive Regulation Of Cytokine Biosynthetic ProcessPositive Regulation Of MAPKKK CascadePositive Regulation Of DNA BindingRegulation Of Biological ProcessActivation Of Protein Kinase ActivityRegulation Of I-kappaB Kinase/NF-kappaB CascadeCell ActivationCytokine ProductionPositive Regulation Of JNK CascadeMulticellular Organismal ProcessResponse To StimulusActivation Of Immune ResponsePositive Regulation Of Immune System ProcessPositive Regulation Of I-kappaB Kinase/NF-kappaB CascadeRegulation Of Lymphocyte ActivationRegulation Of Cell ActivationInflammatory ResponseLeukocyte ActivationImmune System ProcessRegulation Of Leukocyte ActivationRegulation Of Cellular ProcessRegulation Of Innate Immune ResponsePositive Regulation Of Defense ResponsePositive Regulation Of Innate Immune ResponsePositive Regulation Of Leukocyte ProliferationPositive Regulation Of Mononuclear Cell ProliferationPositive Regulation Of Lymphocyte ProliferationResponse To Biotic StimulusActivation Of Innate Immune ResponsePositive Regulation Of Cytokine ProductionToll-like Receptor Signaling PathwayI-kappaB Kinase/NF-kappaB CascadePositive Regulation Of Interferon-beta Biosynthetic ProcessRegulation Of Interferon-beta Biosynthetic ProcessRegulation Of Interferon-beta ProductionRegulation Of Type I Interferon ProductionInnate Immune ResponseActivation Of NF-kappaB-inducing Kinase ActivityRegulation Of Interleukin-6 ProductionResponse To Other OrganismRegulation Of Tumor Necrosis Factor ProductionRegulation Of B Cell ActivationPositive Regulation Of Interleukin-6 ProductionRegulation Of Macrophage Cytokine ProductionResponse To BacteriumPositive Regulation Of Lymphocyte ActivationPositive Regulation Of Leukocyte ActivationPositive Regulation Of Cell ActivationPositive Regulation Of Tumor Necrosis Factor ProductionRegulation Of Macromolecule Biosynthetic ProcessPositive Regulation Of Interleukin-6 Biosynthetic ProcessRegulation Of B Cell ProliferationRegulation Of Cellular Biosynthetic ProcessDefense ResponseRegulation Of Biosynthetic ProcessPositive Regulation Of B Cell ActivationRegulation Of Gene ExpressionDetection Of Biotic StimulusRegulation Of Interleukin-6 Biosynthetic ProcessDefense Response To BacteriumCellular CompartmentReceptor ComplexCell PartCellMolecular FunctionProtein BindingBindingSignal Transducer ActivityMolecular Transducer ActivityTissueMacrophage
  • Arteriogenesis requires toll-like receptor 2 and 4 expression in bone-marrow derived cells. Author : de Groot D, Hoefer IE, Grundmann S, Schoneveld A, Haverslag RT, van Keulen JK, Bot PT, Timmers L, Piek JJ, Pasterkamp G, de Kleijn DP.
    J Mol Cell Cardiol. 2011 Jan;50(1):25-32. doi: 10.1016/j.yjmcc.2010.08.006. Epub 2010 Aug 12.
    PubMed® Id : 20708624

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Provided below are standard protocols that you may find useful for product applications.

BACKGROUND

TLR4, a type I membrane protein that belongs to the Toll-like receptor family, cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). It acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response TLR4 Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR. TLR4 binds to LY96 via the extracellular domain, and to MyD88 and TIRAP via their respective TIR domains. The protein contains 19 leucine-rich (LRR) repeats, and It is highly expressed in heart, spleen, lung and muscle. Lower levels are found in liver and kidney. Interstrain analyses reveal that TLR4 is a polymorphic protein and that the extracellular domain is far more variable than the cytoplasmic domain, which is variable at the C-terminal.