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DKKL1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - DKKL1 Antibody (C-term) AP1525b
    The anti-DKKL1 C-term Pab (Cat. #AP1525b) is used in Western blot to detect DKKL1 in mouse testis tissue lysate.
    detail
  • IHC-P - DKKL1 Antibody (C-term) AP1525b
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q9UK85
Other Accession NP_055234
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 27007 Da
Antigen Region 213-242 aa
Additional Information
Gene ID 27120
Other Names Dickkopf-like protein 1, Cancer/testis antigen 34, CT34, Protein soggy-1, SGY-1, DKKL1, SGY1
Target/Specificity This DKKL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-242 amino acids from the C-terminal region of human DKKL1.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDKKL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DKKL1 (HGNC:16528)
Function Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility.
Cellular Location Secreted {ECO:0000250|UniProtKB:Q9QZL9}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9QZL9}. Note=Localized specifically to the crescent shaped acrosome at the apex of the sperm head {ECO:0000250|UniProtKB:Q9QZL9}
Tissue Location More highly expressed in adult testis than in fetal testis. Exclusively expressed in the testis (at protein level). Intense expression in stages II, III and IV of spermatogenesis, whereas expression is lower in stage I.
Research Areas
Citations (0)
citation

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Background

The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has high similarity to the N-terminus of the dickkopf-3 protein and moderate similarity to that protein's C-terminus though the C-terminal cysteine residues are not conserved.

References

Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003). Krupnik, V.E., et al., Gene 238(2):301-313 (1999).

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$ 365.00
$ 140.00
Cat# AP1525b
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