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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Connexin 31 Antibody (C-term)   

Connexin 31 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Connexin 31 Antibody (C-term) AP1543b
    Western blot analysis of hGJB3-C241 (Cat. #AP1543b) in WiDr cell line lysates (35ug/lane). GJB3 (arrow) was detected using the purified Pab.(2ug/ml)
  • IHC-P - Connexin 31 Antibody (C-term) AP1543b
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75712
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 30818 Da
Antigen Region 227-257 aa
Additional Information
Gene ID 2707
Other Names Gap junction beta-3 protein, Connexin-31, Cx31, GJB3, CX31
Target/Specificity This Connexin 31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-257 amino acids from the C-terminal region of human Connexin 31.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsConnexin 31 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GJB3
Synonyms CX31
Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, gap junction
Research Areas
Citations (0)

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Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.


Mhatre, A.N., et al., Clin. Genet. 63(2):154-159 (2003).
Diestel, S., et al., Biochem. Biophys. Res. Commun. 296(3):721-728 (2002).
Di, W.L., et al., Hum. Mol. Genet. 11(17):2005-2014 (2002).
Gottfried, I., et al., Hum. Mol. Genet. 11(11):1311-1316 (2002).
Wenzel, K., et al., Biochem. Biophys. Res. Commun. 248(3):910-915 (1998).

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Cat# AP1543b
(40 western blots)
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