- CITATIONS: 1
|Application ||WB, E|
|Calculated MW||30419 Da|
|Antigen Region||90-120 aa|
|Other Names||Gap junction beta-4 protein, Connexin-303, Cx303, GJB4|
|Target/Specificity||This Connexin 30.3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-120 amino acids from the N-terminal region of human Connexin 30.3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Connexin 30.3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, gap junction|
Provided below are standard protocols that you may find useful for product applications.
Gap junctions permit direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular communication. Gap junction channels consist of connexin protein subunits encoded by a multigene family. Erythrokeratodermia variabilis (EKV) is an autosomal dominant disorder of keratinization characterized by migratory erythematous lesions and fixed keratotic plaques. Mutations in the GJB3 gene have been reported in some but not all families, although it has been postulated that the absence of connexin 30.3 can be compensated by other connexins.
Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).
Richard, G., et al., J. Invest. Dermatol. 120(4):601-609 (2003).
Macari, F., et al., Am. J. Hum. Genet. 67(5):1296-1301 (2000).
Lopez-Bigas, N., et al., Hum. Mutat. 19 (4), 458 (2002).
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