|Application ||WB, IHC-P, E|
|Calculated MW||30387 Da|
|Antigen Region||87-117 aa|
|Other Names||Gap junction beta-6 protein, Connexin-30, Cx30, GJB6|
|Target/Specificity||This GJB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-117 amino acids from the N-terminal region of human GJB6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GJB6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, gap junction|
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Provided below are standard protocols that you may find useful for product applications.
Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. I Mutations in GJB2 are associated with genetically derived hearing impairments, including autosomal dominant, bilateral, middle to high frequency hearing loss.
Beltramello, M., et al., Biochem. Biophys. Res. Commun. 305(4):1024-1033 (2003).
Common, J.E., et al., Biochem. Biophys. Res. Commun. 298(5):651-656 (2002).
Smith, F.J., et al., J. Invest. Dermatol. 118(3):530-532 (2002).
del Castillo, I., et al., N. Engl. J. Med. 346(4):243-249 (2002).
Pallares-Ruiz, N., et al., Eur. J. Hum. Genet. 10(1):72-76 (2002).
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