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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   NCS1 Antibody (Center)   

NCS1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NCS1 Antibody (Center) AP1551c
    Western blot analysis of NCS1 Antibody (Center) (Cat.# AP1551c) in MCF-7 cell line lysates (35ug/lane). NCS1 (arrow) was detected using the purified Pab.
  • IHC-P - NCS1 Antibody (Center) AP1551c
    Formalin-fixed and paraffin-embedded human breast carcinoma reacted with NCS1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - NCS1 Antibody (Center) AP1551c
    Flow cytometric analysis of ZR-75-1 cells using NCS1 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P62166
Other Accession Q91614, P62168, Q8BNY6, P62167, Q2V8Y7, NP_055101.2
Reactivity Human
Predicted Bovine, Chicken, Mouse, Rat, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 21879 Da
Antigen Region 118-144 aa
Additional Information
Gene ID 23413
Other Names Neuronal calcium sensor 1, NCS-1, Frequenin homolog, Frequenin-like protein, Frequenin-like ubiquitous protein, NCS1, FLUP, FREQ
Target/Specificity This NCS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-144 amino acids from the Central region of human NCS1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNCS1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NCS1
Synonyms FLUP, FREQ
Function Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity).
Cellular Location Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions
Research Areas
Citations (0)

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NCS1 is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. NCS1 regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. This protein is thought to be associated with secretory granules and may be involved in the regulation of neurosecretion.


Koh, P.O., et al., Proc. Natl. Acad. Sci. U.S.A. 100(1):313-317 (2003).
Bourne, Y., et al., J. Biol. Chem. 276(15):11949-11955 (2001).
Burgoyne, R.D., et al., Biochem. J. 353 (Pt 1), 1-12 (2001).

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$ 295.00
$ 99.00
Cat# AP1551c
(40 western blots)
Availability: In Stock
Bulk Size
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