|Application ||WB, IHC-P, E|
|Calculated MW||22313 Da|
|Antigen Region||2-32 aa|
|Other Names||Hippocalcin-like protein 1, Calcium-binding protein BDR-1, HLP2, Visinin-like protein 3, VILIP-3, HPCAL1, BDR1|
|Target/Specificity||This VILIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human VILIP3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VILIP3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.|
|Cellular Location||Membrane; Lipid-anchor|
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Provided below are standard protocols that you may find useful for product applications.
VILIP3 is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. There are two alternatively spliced transcript variants of this gene, with multiple polyadenylation sites. Transcript variant 1 utilizes a different exon and also lacks one exon in the 5' UTR, as compared to variant 2; thus, the encoded protein is the same.
Braunewell, K., et al., Dement Geriatr Cogn Disord 12(2):110-116 (2001). Bernstein, H.G., et al., J Neurocytol 28(8):655-662 (1999). Kobayashi, M., et al., Biochim. Biophys. Acta 1222(3):515-518 (1994). Hidaka, H., et al., Neurosci. Res. 16(2):73-77 (1993). Ivings, L., et al., Biochem. J. 363 (Pt 3), 599-608 (2002).
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