|Application ||WB, E|
|Other Accession||Q9EPC6, Q9JJV2, Q4R4P8, Q09430, NP_444252.1, NP_002619.1|
|Predicted||Bovine, Monkey, Mouse, Rat|
|Calculated MW||15046 Da|
|Antigen Region||110-139 aa|
|Other Names||Profilin-2, Profilin II, PFN2|
|Target/Specificity||This PFN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 110-139 amino acids from the C-terminal region of human PFN2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PFN2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.
Shao, J., et al. Mol. Cell. Biol. 28(17):5196-5208(2008)
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Xu, J., et al. Cell. Signal. 19(7):1575-1582(2007)
Stelzl, U., et al. Cell 122(6):957-968(2005)
Lederer, M., et al. J. Cell. Sci. 118 (PT 2), 331-341 (2005) :
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