ARRDC1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8N5I2 |
Other Accession | NP_689498.1 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 45981 Da |
Antigen Region | 136-164 aa |
Gene ID | 92714 |
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Other Names | Arrestin domain-containing protein 1, ARRDC1 |
Target/Specificity | This ARRDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-164 amino acids from the Central region of human ARRDC1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ARRDC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ARRDC1 (HGNC:28633) |
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Function | Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940). |
Cellular Location | Cell membrane. Note=Also found in extracellular vesicles different from exosomes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ARRDC1 belongs to the arrestin family of proteins.
References
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
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