|Application ||WB, E|
|Calculated MW||45981 Da|
|Antigen Region||136-164 aa|
|Other Names||Arrestin domain-containing protein 1, ARRDC1|
|Target/Specificity||This ARRDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-164 amino acids from the Central region of human ARRDC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ARRDC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating to the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940).|
|Cellular Location||Cell membrane. Note=Also found in extracellular vesicles different from exosomes.|
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Provided below are standard protocols that you may find useful for product applications.
ARRDC1 belongs to the arrestin family of proteins.
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
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