KANK2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q63ZY3 |
Other Accession | NP_056308.3, NP_001129663.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 91174 Da |
Antigen Region | 465-493 aa |
Gene ID | 25959 |
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Other Names | KN motif and ankyrin repeat domain-containing protein 2, Ankyrin repeat domain-containing protein 25, Matrix-remodeling-associated protein 3, SRC-1-interacting protein, SIP, SRC-interacting protein, SRC1-interacting protein, KANK2, ANKRD25, KIAA1518, MXRA3, SIP |
Target/Specificity | This KANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 465-493 amino acids from the Central region of human KANK2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | KANK2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KANK2 |
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Synonyms | ANKRD25, KIAA1518, MXRA3, SIP |
Function | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). |
Cellular Location | Cytoplasm. Mitochondrion |
Tissue Location | Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
ANKRD25 contains 5 ANK repeats. It is strongly expressed in cervix, colon, heart, kidney and lung.
References
Zhu, Y., et al. Biochim. Biophys. Acta 1780(2):128-133(2008)
Zhang, Y., et al. EMBO J. 26(11):2645-2657(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Wistow, G., et al. Mol. Vis. 8, 205-220 (2002) :
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