|Application ||WB, E|
|Other Accession||NP_056308.3, NP_001129663.1|
|Calculated MW||91174 Da|
|Antigen Region||465-493 aa|
|Other Names||KN motif and ankyrin repeat domain-containing protein 2, Ankyrin repeat domain-containing protein 25, Matrix-remodeling-associated protein 3, SRC-1-interacting protein, SIP, SRC-interacting protein, SRC1-interacting protein, KANK2, ANKRD25, KIAA1518, MXRA3, SIP|
|Target/Specificity||This KANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 465-493 amino acids from the Central region of human KANK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KANK2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ANKRD25, KIAA1518, MXRA3, SIP|
|Function||Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500). May be involved in promotion of cell proliferation (By similarity).|
|Cellular Location||Cytoplasm. Mitochondrion.|
|Tissue Location||Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ANKRD25 contains 5 ANK repeats. It is strongly expressed in cervix, colon, heart, kidney and lung.
Zhu, Y., et al. Biochim. Biophys. Acta 1780(2):128-133(2008)
Zhang, Y., et al. EMBO J. 26(11):2645-2657(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Wistow, G., et al. Mol. Vis. 8, 205-220 (2002) :
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