|Application ||WB, E|
|Calculated MW||102032 Da|
|Antigen Region||439-467 aa|
|Other Names||Chordin, CHRD|
|Target/Specificity||This CHRD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 439-467 amino acids from the Central region of human CHRD.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CHRD Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).|
|Tissue Location||Expressed at the highest level in liver.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequence has not been determined.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Kwong, F.N., et al. J. Orthop. Res. 27(6):752-757(2009)
Kwong, F.N., et al. Int Orthop 33(1):281-288(2009)
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