|Application ||WB, E|
|Other Accession||P46684, NP_003403.2|
|Calculated MW||48309 Da|
|Antigen Region||6-34 aa|
|Other Names||Zinc finger protein ZIC 1, Zinc finger protein 201, Zinc finger protein of the cerebellum 1, ZIC1, ZIC, ZNF201|
|Target/Specificity||This ZIC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human ZIC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZIC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'- TGGGTGGTC-3' (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression.|
|Tissue Location||CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.
Brill, E., et al. Cancer Res. 70(17):6891-6901(2010)
Wang, L.J., et al. Biochem. Biophys. Res. Commun. 379(4):959-963(2009)
Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009)
Arora, A., et al. RNA 14(7):1290-1296(2008)
Pourebrahim, R., et al. FEBS Lett. 581(26):5122-5126(2007)
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