|Application ||WB, E|
|Other Accession||NP_065196.1, NP_001116436.1|
|Calculated MW||97458 Da|
|Antigen Region||720-748 aa|
|Other Names||Serine/threonine-protein phosphatase 4 regulatory subunit 3B, SMEK homolog 2, SMEK2, KIAA1387, PP4R3B, PPP4R3B|
|Target/Specificity||This SMEK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 720-748 amino acids from the C-terminal region of human SMEK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SMEK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=In interphase localized in the cytoplasm and (with higher levels) the nucleus. During metaphase located in pericentriolar regions|
|Tissue Location||Moderately expressed in tissues and specific brain regions examined.|
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Provided below are standard protocols that you may find useful for product applications.
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers.
Chowdhury, D., et al. Mol. Cell 31(1):33-46(2008)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Gingras, A.C., et al. Mol. Cell Proteomics 4(11):1725-1740(2005)
Mendoza, M.C., et al. Mol. Cell. Biol. 25(17):7839-7853(2005)
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