|Application ||WB, E|
|Other Accession||Q8BIH0, Q5F3U0, NP_001139400.1, NP_078821.2|
|Calculated MW||110324 Da|
|Antigen Region||909-937 aa|
|Other Names||Histone deacetylase complex subunit SAP130, 130 kDa Sin3-associated polypeptide, Sin3-associated polypeptide p130, SAP130|
|Target/Specificity||This SAP130 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 909-937 amino acids from the C-terminal region of human SAP130.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SAP130 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.|
|Tissue Location||Expressed in various cancer cell ines.|
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Provided below are standard protocols that you may find useful for product applications.
SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Truty, M.J., et al. J. Biol. Chem. 284(10):6291-6300(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Fleischer, T.C., et al. Mol. Cell. Biol. 23(10):3456-3467(2003)
Martinez, E., et al. Mol. Cell. Biol. 21(20):6782-6795(2001)
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