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CD200R1 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CD200R1 Antibody (C-term) AP16040b
    CD200R1 Antibody (C-term) (Cat. #AP16040b) western blot analysis in MDA-MB468 cell line lysates (35ug/lane).This demonstrates the CD200R1 antibody detected the CD200R1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8TD46
Other Accession A5D7V5, NP_620386.1, NP_620385.1
Reactivity Human
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 39041 Da
Antigen Region 275-303 aa
Additional Information
Gene ID 131450
Other Names Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1, CD200R1, CD200R, CRTR2, MOX2R, OX2R
Target/Specificity This CD200R1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-303 amino acids from the C-terminal region of human CD200R1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD200R1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD200R1
Synonyms CD200R, CRTR2, MOX2R, OX2R
Function Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro- inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.
Cellular Location [Isoform 1]: Cell membrane; Single-pass type I membrane protein [Isoform 2]: Secreted.
Tissue Location Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.
Research Areas
Citations (0)
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Background

This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.

References

Luo, X.G., et al. Neurochem. Res. 35(4):540-547(2010)
Mihrshahi, R., et al. J. Immunol. 183(8):4879-4886(2009)
Koning, N., et al. J. Neuropathol. Exp. Neurol. 68(2):159-167(2009)
Meuth, S.G., et al. J. Neuroimmunol. 194 (1-2), 62-69 (2008) :
Wang, X.J., et al. J Neuroimmune Pharmacol 2(3):259-264(2007)

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$ 182.50
$ 70.00
Cat# AP16040b
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