|Application ||WB, E|
|Other Accession||Q62725, P70353, Q5E9X1, NP_055038.2, NP_001136059.1, NP_001136062.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||50302 Da|
|Antigen Region||100-129 aa|
|Other Names||Nuclear transcription factor Y subunit gamma, CAAT box DNA-binding protein subunit C, Nuclear transcription factor Y subunit C, NF-YC, Transactivator HSM-1/2, NFYC|
|Target/Specificity||This NFYC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-129 amino acids from the N-terminal region of human NFYC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NFYC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene.
Ichikawa, S., et al. J. Bone Miner. Res. 25(8):1821-1829(2010)
Murai-Takeda, A., et al. J. Biol. Chem. 285(11):8084-8093(2010)
Ceribelli, M., et al. J. Biol. Chem. 284(49):34189-34200(2009)
Yamanaka, K., et al. Genomics 94(4):219-227(2009)
Horikawa, Y., et al. Clin. Cancer Res. 14(23):7956-7962(2008)
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