|Application ||WB, E|
|Other Accession||P21818, P55821, Q90987, NP_008960.2|
|Predicted||Chicken, Mouse, Rat|
|Calculated MW||20828 Da|
|Antigen Region||145-173 aa|
|Other Names||Stathmin-2, Superior cervical ganglion-10 protein, Protein SCG10, STMN2, SCG10, SCGN10|
|Target/Specificity||This STMN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-173 amino acids from the C-terminal region of human STMN2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||STMN2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Golgi apparatus. Endosome. Cell projection, lamellipodium Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia.|
|Tissue Location||Neuron specific.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6.
Paradis, V., et al. Am. J. Pathol. 177(4):1791-1797(2010)
Rowe, D.D., et al. Brain Res. (2010) In press :
Alves, M.M., et al. Hum. Mol. Genet. 19(18):3642-3651(2010)
Xu, H., et al. J. Biol. Chem. 285(6):3548-3553(2010)
Mead, S., et al. Lancet Neurol 8(1):57-66(2009)
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