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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   XPO5 Antibody (C-term)   

XPO5 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - XPO5 Antibody (C-term) AP16050B
    XPO5 Antibody (C-term) (Cat. #AP16050b) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the XPO5 antibody detected the XPO5 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HAV4
Other Accession NP_065801.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 136311 Da
Antigen Region 1123-1152 aa
Additional Information
Gene ID 57510
Other Names Exportin-5, Exp5, Ran-binding protein 21, XPO5, KIAA1291, RANBP21
Target/Specificity This XPO5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1123-1152 amino acids from the C-terminal region of human XPO5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsXPO5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name XPO5
Synonyms KIAA1291, RANBP21
Function Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.
Cellular Location Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm
Tissue Location Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas
Research Areas
Citations (0)

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Exportin-5 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments.[supplied by OMIM].


Melo, S.A., et al. Cancer Cell 18(4):303-315(2010)
Kim, J.S., et al. Mol. Carcinog. 49(10):913-921(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Wilker, E.H., et al. Environ. Health Perspect. 118(7):943-948(2010)
Boni, V., et al. Pharmacogenomics J. (2010) In press :

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$ 295.00
$ 99.00
Cat# AP16050B
(40 western blots)
Availability: In Stock
Bulk Size
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