|Application ||WB, E|
|Other Accession||Q99KG3, NP_005667.2, NP_690595.1|
|Calculated MW||103533 Da|
|Antigen Region||85-113 aa|
|Other Names||RNA-binding protein 10, G patch domain-containing protein 9, RNA-binding motif protein 10, RNA-binding protein S1-1, S1-1, RBM10, DXS8237E, GPATC9, GPATCH9, KIAA0122|
|Target/Specificity||This RBM10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-113 amino acids from the N-terminal region of human RBM10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RBM10 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DXS8237E, GPATC9, GPATCH9, KIAA0122|
|Function||May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity).|
|Cellular Location||Nucleus. Note=In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains)|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene contains RNA recognition motif found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. In vitro studies showed that the rat homolog bound to RNA homopolymers, with a preference for G and U polyribonucleotides. This gene is part of a gene cluster on chromosome Xp11.23, and its 3' end lies within 20 kb upstream of UBE1. Two transcript variants encoding different isoforms have been identified for this gene.
Johnston, J.J., et al. Am. J. Hum. Genet. 86(5):743-748(2010)
Inoue, A., et al. Biol. Cell 100(9):523-535(2008)
Dephoure, N., et al. Proc. Natl. Acad. Sci. U.S.A. 105(31):10762-10767(2008)
Martin-Garabato, E., et al. Cancer Genomics Proteomics 5 (3-4), 169-173 (2008) :
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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