|Application ||WB, E|
|Calculated MW||38243 Da|
|Antigen Region||105-133 aa|
|Other Names||Nuclear migration protein nudC, Nuclear distribution protein C homolog, NUDC|
|Target/Specificity||This NUDC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-133 amino acids from the Central region of human NUDC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NUDC Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.|
|Cellular Location||Cytoplasm, cytoskeleton. Nucleus. Note=In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern|
|Tissue Location||Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.|
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Provided below are standard protocols that you may find useful for product applications.
NudC was first identified as a regulator of nuclear movement in the asexual reproductive cycle of the filamentous fungus Aspergillus nidulans. Human NUDC is a nuclear movement protein that associates with dynein (see DYNC1H1; MIM 600112) (Aumais et al., 2003 [PubMed 12679384]).
Zhu, X.J., et al. J. Biol. Chem. 285(39):29903-29910(2010)
Chen, W.M., et al. J. Biol. Chem. 285(34):26697-26709(2010)
Pang, S.F., et al. Exp. Cell Res. 315(20):3563-3573(2009)
Tang, Y.S., et al. Leukemia 22(5):1018-1025(2008)
Zhang, Y.P., et al. Exp. Cell Res. 313(15):3210-3221(2007)
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