|Application ||WB, E|
|Other Accession||Q6AYC4, P24452, NP_001738.2|
|Calculated MW||38499 Da|
|Antigen Region||181-209 aa|
|Other Names||Macrophage-capping protein, Actin regulatory protein CAP-G, CAPG, AFCP, MCP|
|Target/Specificity||This CAPG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-209 amino acids from the Central region of human CAPG.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CAPG Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.|
|Cellular Location||Cytoplasm. Nucleus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
|Tissue Location||Macrophages and macrophage-like cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed, but have not been fully described. [provided by RefSeq].
Li, M.X., et al. Med. Oncol. 27(1):134-144(2010)
Burillo, E., et al. Atherosclerosis 207(1):32-37(2009)
Zhang, R., et al. Am. J. Respir. Cell Mol. Biol. 41(4):467-475(2009)
Hubert, T., et al. Biochem. Biophys. Res. Commun. 380(1):166-170(2009)
Chen, M., et al. J. Biol. Chem. 284(3):1484-1494(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.