|Application ||WB, E|
|Calculated MW||166674 Da|
|Antigen Region||798-827 aa|
|Other Names||C-type mannose receptor 2, C-type lectin domain family 13 member E, Endocytic receptor 180, Macrophage mannose receptor 2, Urokinase-type plasminogen activator receptor-associated protein, UPAR-associated protein, Urokinase receptor-associated protein, CD280, MRC2, CLEC13E, ENDO180, KIAA0709, UPARAP|
|Target/Specificity||This MRC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 798-827 amino acids from the Central region of human MRC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MRC2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLEC13E, ENDO180, KIAA0709, UPARAP|
|Function||May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon Expressed in endothelial cells, fibroblasts and macrophages Highly expressed in fetal lung and kidney|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
MRC2 is a recycling endocytic receptor that functions in cell motility and remodeling of the extracellular matrix by promoting cell migration and uptake of collagens for intracellular degradation (Wienke et al., 2007 [PubMed 17974964]).[supplied by OMIM].
Messaritou, G., et al. J. Cell. Sci. 122 (PT 22), 4042-4048 (2009) :
Wu, X., et al. Cancer Prev Res (Phila Pa) 2(7):617-624(2009)
Wienke, D., et al. Cancer Res. 67(21):10230-10240(2007)
Sulek, J., et al. J. Histochem. Cytochem. 55(4):347-353(2007)
Johnson, J.M., et al. Science 302(5653):2141-2144(2003)
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