|Application ||WB, E|
|Calculated MW||38096 Da|
|Antigen Region||1-30 aa|
|Other Names||Cyclin-O, CCNO|
|Target/Specificity||This CCNO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CCNO.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCNO Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.|
|Cellular Location||Cytoplasm. Note=Localizes to the apical part of cytoplasm|
|Tissue Location||Present in respiratory cells (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 term is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes.
Schmutz, J., et al. Nature 431(7006):268-274(2004)
Muller, S.J., et al. J. Biol. Chem. 268(2):1310-1319(1993)
Muller, S.J., et al. Biochim. Biophys. Acta 1088(2):197-207(1991)
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